{"id":251,"date":"2023-09-25T13:56:00","date_gmt":"2023-09-25T06:56:00","guid":{"rendered":"https:\/\/score.ccme.or.th\/ccme-wp\/?p=251"},"modified":"2023-09-25T13:56:00","modified_gmt":"2023-09-25T06:56:00","slug":"sorafenat-200","status":"publish","type":"post","link":"https:\/\/score.ccme.or.th\/ccme-wp\/2023\/09\/25\/sorafenat-200\/","title":{"rendered":"Sorafenat 200"},"content":{"rendered":"\n<figure class=\"wp-block-image aligncenter size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"2000\" height=\"2000\" data-attachment-id=\"203\" data-permalink=\"https:\/\/score.ccme.or.th\/ccme-wp\/sorafenat-001\/\" data-orig-file=\"https:\/\/score.ccme.or.th\/ccme-wp\/wp-content\/uploads\/2023\/09\/sorafenat-001.png\" data-orig-size=\"2000,2000\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"sorafenat-001\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/score.ccme.or.th\/ccme-wp\/wp-content\/uploads\/2023\/09\/sorafenat-001.png\" data-large-file=\"https:\/\/score.ccme.or.th\/ccme-wp\/wp-content\/uploads\/2023\/09\/sorafenat-001.png\" src=\"https:\/\/score.ccme.or.th\/ccme-wp\/wp-content\/uploads\/2023\/09\/sorafenat-001.png?w=1024\" alt=\"\" class=\"wp-image-203\" \/><\/figure>\n\n\n\n<p><strong>Indication<\/strong><\/p>\n\n\n\n<p><strong>\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e0a\u0e19\u0e34\u0e14 Hepatocellular carcinoma<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sorafenib \u0e43\u0e0a\u0e49\u0e43\u0e19\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e0a\u0e19\u0e34\u0e14 hepatocellular carcinoma \u0e17\u0e35\u0e48\u0e44\u0e21\u0e48\u0e2a\u0e32\u0e21\u0e32\u0e23\u0e16\u0e23\u0e31\u0e01\u0e29\u0e32\u0e14\u0e49\u0e27\u0e22\u0e01\u0e32\u0e23\u0e1c\u0e48\u0e32\u0e15\u0e31\u0e14\u0e41\u0e25\u0e30\u0e01\u0e32\u0e23\u0e09\u0e35\u0e14\u0e40\u0e04\u0e21\u0e35\u0e1a\u0e33\u0e1a\u0e31\u0e14\u0e40\u0e09\u0e1e\u0e32\u0e30\u0e17\u0e35\u0e48 \u0e43\u0e2b\u0e49\u0e14\u0e39\u0e23\u0e32\u0e22\u0e25\u0e30\u0e40\u0e2d\u0e35\u0e22\u0e14\u0e43\u0e19\u0e41\u0e19\u0e27\u0e17\u0e32\u0e07\u0e1b\u0e0f\u0e34\u0e1a\u0e31\u0e15\u0e34\u0e01\u0e32\u0e23\u0e14\u0e39\u0e41\u0e25\u0e23\u0e31\u0e01\u0e29\u0e32\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e42\u0e23\u0e04\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e41\u0e25\u0e30\u0e17\u0e48\u0e2d\u0e19\u0e4d\u0e49\u0e32\u0e14\u0e35<\/li>\n<\/ul>\n\n\n\n<p><strong>\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e44\u0e15\u0e0a\u0e19\u0e34\u0e14 Renal cell carcinomaSorafenib<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0e43\u0e0a\u0e49\u0e43\u0e19\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e17\u0e35\u0e48\u0e44\u0e15\u0e23\u0e30\u0e22\u0e30\u0e25\u0e38\u0e01\u0e25\u0e32\u0e21<\/li>\n<\/ul>\n\n\n\n<p><strong>\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e48\u0e2d\u0e21\u0e44\u0e17\u0e23\u0e2d\u0e22\u0e14\u0e4c\u0e0a\u0e19\u0e34\u0e14 differentiated<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sorafenib \u0e43\u0e0a\u0e49\u0e43\u0e19\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e48\u0e2d\u0e21\u0e44\u0e17\u0e23\u0e2d\u0e22\u0e14\u0e4c\u0e0a\u0e19\u0e34\u0e14 differentiated \u0e23\u0e30\u0e22\u0e30\u0e25\u0e38\u0e01\u0e25\u0e32\u0e21\u0e40\u0e09\u0e1e\u0e32\u0e30\u0e17\u0e35\u0e48\u0e2b\u0e23\u0e37\u0e2d\u0e23\u0e30\u0e22\u0e30\u0e41\u0e1e\u0e23\u0e48\u0e01\u0e23\u0e30\u0e08\u0e32\u0e22\u0e17\u0e35\u0e48\u0e23\u0e31\u0e01\u0e29\u0e32\u0e14\u0e49\u0e27\u0e22\u0e41\u0e23\u0e48\u0e23\u0e31\u0e07\u0e2a\u0e35\u0e44\u0e2d\u0e42\u0e2d\u0e14\u0e35\u0e19 (radioactive iodine) \u0e44\u0e21\u0e48\u0e44\u0e14\u0e49\u0e1c\u0e25<\/li>\n<\/ul>\n\n\n\n<p><strong>Qualitative Quantitative Composition<\/strong><\/p>\n\n\n\n<p>Sorafenib Tosylate 200 mg<\/p>\n\n\n\n<p><strong>Pharmaceutical Dose Form<\/strong><\/p>\n\n\n\n<p>Film coated tablet<\/p>\n\n\n\n<p><strong>Dose And Administration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e14\u0e49\u0e27\u0e22\u0e22\u0e32 sorafenib \u0e04\u0e27\u0e23\u0e17\u0e33\u0e20\u0e32\u0e22\u0e43\u0e15\u0e49\u0e41\u0e1e\u0e17\u0e22\u0e4c\u0e1c\u0e39\u0e49\u0e40\u0e0a\u0e35\u0e48\u0e22\u0e27\u0e0a\u0e32\u0e0d\u0e14\u0e49\u0e32\u0e19\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07<\/li>\n\n\n\n<li>\u0e02\u0e19\u0e32\u0e14\u0e17\u0e35\u0e48\u0e41\u0e19\u0e30\u0e19\u0e33\u0e43\u0e19\u0e1c\u0e39\u0e49\u0e43\u0e2b\u0e0d\u0e48\u0e02\u0e2d\u0e07\u0e22\u0e32 sorafenib \u0e04\u0e37\u0e2d 400 \u0e21\u0e34\u0e25\u0e25\u0e34\u0e01\u0e23\u0e31\u0e21 (\u0e02\u0e19\u0e32\u0e14 200 \u0e21\u0e34\u0e25\u0e25\u0e34\u0e01\u0e23\u0e31\u0e21 \u0e08\u0e33\u0e19\u0e27\u0e19 2 \u0e40\u0e21\u0e47\u0e14) \u0e27\u0e31\u0e19\u0e25\u0e30 2 \u0e04\u0e23\u0e31\u0e49\u0e07 (\u0e40\u0e17\u0e48\u0e32\u0e01\u0e31\u0e1a\u0e02\u0e19\u0e32\u0e14 800 \u0e21\u0e34\u0e25\u0e25\u0e34\u0e01\u0e23\u0e31\u0e21\u0e15\u0e48\u0e2d\u0e27\u0e31\u0e19)<\/li>\n\n\n\n<li>\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e04\u0e27\u0e23\u0e14\u0e33\u0e40\u0e19\u0e34\u0e19\u0e01\u0e32\u0e23\u0e2d\u0e22\u0e48\u0e32\u0e07\u0e15\u0e48\u0e2d\u0e40\u0e19\u0e37\u0e48\u0e2d\u0e07\u0e08\u0e19\u0e01\u0e23\u0e30\u0e17\u0e31\u0e48\u0e07\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e44\u0e21\u0e48\u0e44\u0e14\u0e49\u0e23\u0e31\u0e1a\u0e1b\u0e23\u0e30\u0e42\u0e22\u0e0a\u0e19\u0e4c\u0e17\u0e32\u0e07\u0e04\u0e25\u0e34\u0e19\u0e34\u0e01\u0e08\u0e32\u0e01\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e2d\u0e35\u0e01\u0e15\u0e48\u0e2d\u0e44\u0e1b \u0e2b\u0e23\u0e37\u0e2d\u0e08\u0e19\u0e01\u0e23\u0e30\u0e17\u0e31\u0e48\u0e07\u0e40\u0e01\u0e34\u0e14\u0e04\u0e27\u0e32\u0e21\u0e40\u0e1b\u0e47\u0e19\u0e1e\u0e34\u0e29\u0e17\u0e35\u0e48\u0e44\u0e21\u0e48\u0e2a\u0e32\u0e21\u0e32\u0e23\u0e16\u0e23\u0e31\u0e1a\u0e44\u0e14\u0e49<\/li>\n<\/ul>\n\n\n\n<p><strong>Contraindications<\/strong><\/p>\n\n\n\n<p>\u0e2b\u0e49\u0e32\u0e21\u0e43\u0e0a\u0e49\u0e43\u0e19\u0e1c\u0e39\u0e49\u0e17\u0e35\u0e48\u0e41\u0e1e\u0e49\u0e22\u0e32 sorafenib \u0e2b\u0e23\u0e37\u0e2d\u0e2a\u0e48\u0e27\u0e19\u0e1b\u0e23\u0e30\u0e01\u0e2d\u0e1a\u0e2d\u0e37\u0e48\u0e19<\/p>\n\n\n\n<p><strong>Special Warnings Precautions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0e2b\u0e25\u0e35\u0e01\u0e40\u0e25\u0e35\u0e48\u0e22\u0e07\u0e01\u0e32\u0e23\u0e15\u0e31\u0e49\u0e07\u0e04\u0e23\u0e23\u0e20\u0e4c\u0e43\u0e19\u0e23\u0e30\u0e2b\u0e27\u0e48\u0e32\u0e07\u0e17\u0e35\u0e48\u0e44\u0e14\u0e49\u0e23\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e14\u0e49\u0e27\u0e22 sorafenib<\/li>\n\n\n\n<li>\u0e04\u0e27\u0e23\u0e07\u0e14\u0e43\u0e2b\u0e49\u0e19\u0e21\u0e1a\u0e38\u0e15\u0e23\u0e43\u0e19\u0e23\u0e30\u0e2b\u0e27\u0e48\u0e32\u0e07\u0e17\u0e35\u0e48\u0e44\u0e14\u0e49\u0e23\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e14\u0e49\u0e27\u0e22 sorafenib<\/li>\n\n\n\n<li>\u0e1b\u0e0f\u0e34\u0e01\u0e34\u0e23\u0e34\u0e22\u0e32\u0e17\u0e32\u0e07\u0e1c\u0e34\u0e27\u0e2b\u0e19\u0e31\u0e07\u0e15\u0e48\u0e2d\u0e21\u0e37\u0e2d\u0e41\u0e25\u0e30\u0e40\u0e17\u0e49\u0e32 (\u0e1c\u0e37\u0e48\u0e19\u0e17\u0e35\u0e48\u0e1d\u0e48\u0e32\u0e21\u0e37\u0e2d\u0e41\u0e25\u0e30\u0e1d\u0e48\u0e32\u0e40\u0e17\u0e49\u0e32 (palmar-plantar erythrodysaesthesia)) \u0e41\u0e25\u0e30\u0e1c\u0e37\u0e48\u0e19\u0e41\u0e14\u0e07\u0e1e\u0e1a\u0e1a\u0e48\u0e2d\u0e22\u0e08\u0e32\u0e01\u0e01\u0e32\u0e23\u0e43\u0e0a\u0e49\u0e22\u0e32 sorafenib<\/li>\n\n\n\n<li>\u0e04\u0e27\u0e32\u0e21\u0e14\u0e31\u0e19\u0e42\u0e25\u0e2b\u0e34\u0e15\u0e2a\u0e39\u0e07<\/li>\n\n\n\n<li>\u0e20\u0e32\u0e27\u0e30\u0e19\u0e49\u0e33\u0e15\u0e32\u0e25\u0e43\u0e19\u0e40\u0e25\u0e37\u0e2d\u0e14\u0e15\u0e48\u0e33<\/li>\n\n\n\n<li>\u0e20\u0e32\u0e27\u0e30\u0e15\u0e01\u0e40\u0e25\u0e37\u0e2d\u0e14<\/li>\n\n\n\n<li>\u0e20\u0e32\u0e27\u0e30\u0e2b\u0e31\u0e27\u0e43\u0e08\u0e02\u0e32\u0e14\u0e40\u0e25\u0e37\u0e2d\u0e14<\/li>\n\n\n\n<li>\u0e20\u0e32\u0e27\u0e30\u0e15\u0e31\u0e1a\u0e1a\u0e01\u0e1e\u0e23\u0e48\u0e2d\u0e07<\/li>\n\n\n\n<li>\u0e01\u0e32\u0e23\u0e43\u0e0a\u0e49\u0e22\u0e32\u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e1a\u0e22\u0e32 Warfarin<\/li>\n<\/ul>\n\n\n\n<p><strong>Interaction<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0e04\u0e27\u0e23\u0e23\u0e30\u0e21\u0e31\u0e14\u0e23\u0e30\u0e27\u0e31\u0e07\u0e40\u0e21\u0e37\u0e48\u0e2d\u0e43\u0e0a\u0e49\u0e22\u0e32 sorafenib \u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e1a\u0e22\u0e32\u0e01\u0e25\u0e38\u0e48\u0e21\u0e17\u0e35\u0e48\u0e40\u0e21\u0e15\u0e32\u0e1a\u0e2d\u0e44\u0e25\u0e0b\u0e4c\u0e2b\u0e23\u0e37\u0e2d\u0e02\u0e31\u0e1a\u0e22\u0e32\u0e42\u0e14\u0e22\u0e2a\u0e48\u0e27\u0e19\u0e43\u0e2b\u0e0d\u0e48\u0e1c\u0e48\u0e32\u0e19\u0e17\u0e32\u0e07 UGT1A1 (\u0e40\u0e0a\u0e48\u0e19 irinotecan) \u0e2b\u0e23\u0e37\u0e2d UGT1A9<\/li>\n\n\n\n<li>\u0e04\u0e27\u0e23\u0e23\u0e30\u0e21\u0e31\u0e14\u0e23\u0e30\u0e27\u0e31\u0e07\u0e01\u0e32\u0e23\u0e43\u0e0a\u0e49\u0e22\u0e32 sorafenib \u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e1a\u0e22\u0e32 docetaxel<\/li>\n\n\n\n<li>\u0e01\u0e32\u0e23\u0e43\u0e0a\u0e49\u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e1a neomycin \u0e2b\u0e23\u0e37\u0e2d\u0e01\u0e25\u0e38\u0e48\u0e21\u0e22\u0e32\u0e15\u0e49\u0e32\u0e19\u0e08\u0e38\u0e25\u0e0a\u0e35\u0e1e\u0e17\u0e35\u0e48\u0e23\u0e1a\u0e01\u0e27\u0e19\u0e2a\u0e21\u0e14\u0e38\u0e25\u0e17\u0e32\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e19\u0e34\u0e40\u0e27\u0e28\u0e02\u0e2d\u0e07\u0e40\u0e0a\u0e37\u0e49\u0e2d\u0e43\u0e19\u0e17\u0e32\u0e07\u0e40\u0e14\u0e34\u0e19\u0e2d\u0e32\u0e2b\u0e32\u0e23\u0e2d\u0e32\u0e08\u0e17\u0e33\u0e43\u0e2b\u0e49\u0e25\u0e14\u0e1b\u0e23\u0e34\u0e21\u0e32\u0e13\u0e22\u0e32\u0e17\u0e35\u0e48\u0e2d\u0e2d\u0e01\u0e24\u0e17\u0e18\u0e34\u0e4c\u0e02\u0e2d\u0e07\u0e22\u0e32 sorafenib (\u0e14\u0e39\u0e2b\u0e31\u0e27\u0e02\u0e49\u0e2d 4.5)<\/li>\n\n\n\n<li>\u0e04\u0e27\u0e23\u0e04\u0e33\u0e19\u0e36\u0e07\u0e16\u0e36\u0e07\u0e04\u0e27\u0e32\u0e21\u0e40\u0e2a\u0e35\u0e48\u0e22\u0e07\u0e17\u0e35\u0e48\u0e04\u0e27\u0e32\u0e21\u0e40\u0e02\u0e49\u0e21\u0e02\u0e49\u0e19\u0e43\u0e19\u0e1e\u0e25\u0e32\u0e2a\u0e21\u0e32\u0e02\u0e2d\u0e07\u0e22\u0e32 sorafenib \u0e01\u0e48\u0e2d\u0e19\u0e40\u0e23\u0e34\u0e48\u0e21\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e14\u0e49\u0e27\u0e22\u0e22\u0e32\u0e15\u0e49\u0e32\u0e19\u0e08\u0e38\u0e25\u0e0a\u0e35\u0e1e<\/li>\n<\/ul>\n\n\n\n<p><strong>License Name<\/strong><\/p>\n\n\n\n<p>\u0e1a\u0e23\u0e34\u0e29\u0e31\u0e17 \u0e41\u0e2d\u0e15\u0e41\u0e25\u0e19\u0e15\u0e49\u0e32 \u0e40\u0e21\u0e14\u0e14\u0e34\u0e04\u0e41\u0e04\u0e23\u0e4c \u0e08\u0e33\u0e01\u0e31\u0e14<\/p>\n\n\n\n<p><strong>Distributor Name<\/strong><\/p>\n\n\n\n<p>\u0e1a\u0e23\u0e34\u0e29\u0e31\u0e17 \u0e41\u0e2d\u0e15\u0e41\u0e25\u0e19\u0e15\u0e49\u0e32 \u0e40\u0e21\u0e14\u0e14\u0e34\u0e04\u0e41\u0e04\u0e23\u0e4c \u0e08\u0e33\u0e01\u0e31\u0e14<\/p>\n\n\n\n<p><strong>Marketing Authorisation Number<\/strong><\/p>\n\n\n\n<p>1C 1\/66 (NG)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Indication \u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e0a\u0e19\u0e34\u0e14 Hepatocellular carcinoma \u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e44\u0e15\u0e0a\u0e19\u0e34\u0e14 Renal cell carcinomaSorafenib \u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e48\u0e2d\u0e21\u0e44\u0e17\u0e23\u0e2d\u0e22\u0e14\u0e4c\u0e0a\u0e19\u0e34\u0e14 differentiated Qualitative Quantitative Composition Sorafenib Tosylate 200 mg Pharmaceutical Dose Form Film coated tablet Dose And Administration Contraindications \u0e2b\u0e49\u0e32\u0e21\u0e43\u0e0a\u0e49\u0e43\u0e19\u0e1c\u0e39\u0e49\u0e17\u0e35\u0e48\u0e41\u0e1e\u0e49\u0e22\u0e32 sorafenib \u0e2b\u0e23\u0e37\u0e2d\u0e2a\u0e48\u0e27\u0e19\u0e1b\u0e23\u0e30\u0e01\u0e2d\u0e1a\u0e2d\u0e37\u0e48\u0e19 Special Warnings Precautions Interaction License Name \u0e1a\u0e23\u0e34\u0e29\u0e31\u0e17 \u0e41\u0e2d\u0e15\u0e41\u0e25\u0e19\u0e15\u0e49\u0e32 \u0e40\u0e21\u0e14\u0e14\u0e34\u0e04\u0e41\u0e04\u0e23\u0e4c \u0e08\u0e33\u0e01\u0e31\u0e14 Distributor Name \u0e1a\u0e23\u0e34\u0e29\u0e31\u0e17 \u0e41\u0e2d\u0e15\u0e41\u0e25\u0e19\u0e15\u0e49\u0e32 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